Pegylated Mechano Growth Factor (PEG MGF) is a splice variant of IGF1 and is found to have therapeutic benefits in muscular atrophy, neuropathic pain and multiple sclerosis. PEG-MGF plays an important role and is considered import­ant for the growth of skeletal muscles. PEG-MGF may increase cognitive ability, provide strength to muscles, mental clarity, neuroprotective effect, and muscle regeneration. It also has shown tremendous benefits for development and repair of muscle following injury. PEG-MGF plays a vital role in the lives of human beings and is very beneficial as it provides tremen­dous advantages for the human body, specifically neuropath­ic pain, muscle atrophy, autoimmune disorders, and multiple sclerosis.